Incidence of invasive
fungal infections (IFI) has progressively increased over the past few decades.
Invasive aspergillosis (IA) is associated with the highest morbidity andmortality in immunocompromised patients.
Aspergillus flavus is the
second leading cause of IA affecting mostly upper airways and skin. Invasive
cutaneous asperigillosis (ICA) is a rare condition characterized by more or
less itching macules, papules, plaques or haemorrhagic bullae, potentially
evolving into necrotic ulcers covered by a dark eschar. Primary ICA, deriving
from fungus direct inoculation into an injured site, can be distinguished from
secondary ICA, usually resulting from systemic dissemination of inhaled hyphae
through the blood stream. Immunological deficiency in paediatric
haemato-oncology patients is due both to the malignancy and chemotherapy
regimen, emerging as the main predisposing factors to IFI.
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