The effect of a
live nef-deleted SIVmac 239 construct (SIVΔ nef) was evaluated in rhesus
macaques infected with wild-type SIVmac 239 . Rhesus macaques were inoculated
by intravenous administration of 100 tissue culture infectious doses 50% (TCID
50 ) of SIVmac 239.
All animals had
detectable viremia at 1 week post-inoculation (pi), with peak
viremia (6 to 100 million copies viral RNA/ml plasma) two to three weeks pi. From
week 4 to week 8 pi, virus levels ranged from ~ 10 4 to ~ 10 6 copies/ml, which
is the expected range for SIVmac 239 .
MHC type 1
Phenotyping and week 4 viral load data were used to stratify the animals into 3
groups, which all received 2 consecutive intravenous injections of Placebo or
SIV Δnef at weeks 8 and 10 pi.
No comments:
Post a Comment